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目的:分析类风湿性关节炎(RA)及原发性干燥综合征(PSS)患者血清免疫球蛋白(Ig)及补体水平与健康对照组间的差异,并探讨其可能原因。方法:采用速率散射比浊法检测60例RA、60例PSS患者及40例健康对照者的Ig及补体水平。结果:PSS组和RA组的IgG、IgA的结果均明显高于健康对照组(P<0.05),C3结果明显低于健康对照组(P<0.05),而IgM、C4的结果差异无统计学意义(P>0.05)。与RA组比较,PSS组的IgG、IgA的结果均明显增高(P<0.05),IgM、C3、C4的结果差异无统计学意义(P>0.05)。结论:RA和PSS患者均有明显的体液免疫功能紊乱,其Ig及补体水平在不同的疾病组及在同一疾病的不同个体间存在着差异,定期监测患者Ig及补体水平对病情的判断、病程进展、疗效观察及预后判断都有一定的临床意义。
OBJECTIVE: To analyze the difference of serum immunoglobulin (Ig) and complement levels in patients with rheumatoid arthritis (RA) and primary sjogren’s syndrome (PSS) and healthy controls and to explore the possible causes. Methods: Ig and complement levels in 60 patients with RA, 60 patients with PSS and 40 healthy controls were detected by rate nephelometry. Results: The results of IgG and IgA in PSS group and RA group were significantly higher than those in healthy control group (P <0.05), and the results of C3 were significantly lower than those in healthy control group (P <0.05). The results of IgM and C4 were not statistically different Significance (P> 0.05). Compared with RA group, the results of IgG and IgA in PSS group were significantly increased (P <0.05), while there was no significant difference in IgM, C3 and C4 (P> 0.05). Conclusion: Patients with RA and PSS have significant humoral immune dysfunction. The levels of Ig and complement in different disease groups and in different individuals with the same disease are different. The Ig and complement levels in patients with regular monitoring of disease status, disease duration Progress, efficacy and prognosis of prognosis have some clinical significance.