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目的探讨多参数超声(灰阶、彩色多普勒超声联合超声造影)在评估乳腺癌新辅助化疗疗效方面的价值。方法将接受乳腺癌NAC的31例患者,以术前穿刺病理和术后手术病理为金标准,采用多参数超声对乳腺癌NAC的疗效进行评估。结果(1)病理评估完全缓解8例(13.89%),部分缓解15例(61.11%),病变稳定4例(18.06%)和病变进展4例(6.94%)。(2)常规超声(灰阶超声联合CDFI)评估的灵敏度、特异度和准确度分别为100%、37.5%和83.87%。(3)多参数超声评估为有效22例,无效9例,敏感度、特异度和准确度分别为91.3%、87.5%和90.32%。结论与常规超声评估乳腺癌NAC疗效相比,多参数超声方法可以提高特异度及准确度,增加影像学方法评估NAC疗效的价值。
Objective To investigate the value of multi-parameter ultrasound (grayscale, color Doppler ultrasonography combined with contrast-enhanced ultrasound) in evaluating the efficacy of neoadjuvant chemotherapy for breast cancer. Methods Twenty-one patients with breast cancer NAC were evaluated by preoperative puncture pathology and postoperative surgical pathology with multi-parameter ultrasound to evaluate the efficacy of breast cancer NAC. Results (1) Pathological evaluation of complete remission in 8 cases (13.89%), partial remission in 15 cases (61.11%), stable lesion in 4 cases (18.06%) and lesion progression in 4 cases (6.94%). (2) The sensitivity, specificity and accuracy of conventional ultrasound (gray scale ultrasound combined with CDFI) assessment were 100%, 37.5% and 83.87% respectively. (3) The multi-parameter ultrasound was effective in 22 cases and ineffective in 9 cases. The sensitivity, specificity and accuracy were 91.3%, 87.5% and 90.32% respectively. Conclusion Compared with routine ultrasound in assessing the efficacy of NAC in breast cancer, the multi-parameter ultrasound can improve the specificity and accuracy and increase the value of imaging in evaluating the efficacy of NAC.