论文部分内容阅读
过氧化物酶体增殖物激活受体是一类由配体激活的核转录因子,属于Ⅱ型核受体超家族,由a、β(亦称δ和NUC1)、γ3种亚型组成。其中PPARγ通过调节相关基因的表达,影响糖脂代谢、脂肪形成,并与多种疾病如糖尿病、肥胖、高血压等密切相关。目前研究认为在病理状态下(如高血糖、高胰岛素血症和高脂血症等),IRS-1/PI3K/Akt/NO和IRS-1/RAS/MAPK/ET-1间平衡可能被打破,导致内皮功能失常和胰岛素抵抗(IR)。研究PPARγ在治疗和预防胰岛素抵抗中的机制有着重要的学术价值和临床应用前景。
Peroxisome proliferator-activated receptor is a class of ligand-activated nuclear transcription factor, belongs to type Ⅱ nuclear receptor superfamily, which consists of a, β (also known as δ and NUC1), γ3 subtypes. Which PPARγ regulate the expression of related genes, affecting glucose and lipid metabolism, adipogenesis, and a variety of diseases such as diabetes, obesity, hypertension and so closely related. Current studies suggest that the balance between IRS-1 / PI3K / Akt / NO and IRS-1 / RAS / MAPK / ET-1 may be disrupted in pathological conditions such as hyperglycemia, hyperinsulinemia and hyperlipidemia , Resulting in endothelial dysfunction and insulin resistance (IR). Studying the mechanism of PPARγ in the treatment and prevention of insulin resistance has important academic value and clinical application prospect.