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目的 研究胸苷磷酸化酶 (TP)在进展期胃癌中的表达与癌组织的分化程度、肿瘤内微血管密度(IMVD)及 5 -氟尿嘧啶化疗患者预后的关系。方法 对 6 1例进展期胃癌标本 (患者术后均经过常规的以 5 - FU为主的化疗 )及 30例正常胃粘膜组织进行免疫组化染色测定 TP的表达情况 ;通过 CD34免疫组化染色检测胃癌组织中的IMVD。结果 胃癌细胞的 TP表达阳性率高于正常胃粘膜上皮 (P<0 .0 5 ) ;TP阳性组中 IMVD明显高于 TP阴性组(P<0 .0 0 1) ;TP表达阳性组的 5年生存率及总生存率明显高于 TP表达阴性组 (P<0 .0 5 ) ;胃癌中高、中低分化癌组之间的 TP阳性率无明显差异 (P>0 .0 5 )。结论 胃癌中 TP的表达与胃癌内血管生成及胃癌患者的预后关系密切 ;与胃癌的分化程度无关
Objective To study the relationship between the expression of thymidine phosphorylase (TP) in advanced gastric cancer and the differentiation of cancer tissue, the intracranial microvessel density (IMVD) and the prognosis of 5 - fluorouracil chemotherapy. Methods The expression of TP was detected by immunohistochemical staining in 61 cases of advanced gastric cancer specimens (all patients underwent conventional 5 - FU chemotherapy after operation) and 30 normal gastric mucosa tissues. The expression of TP was detected by CD34 immunohistochemistry Detection of IMVD in gastric cancer tissue. Results The positive rate of TP expression in gastric cancer cells was higher than that in normal gastric mucosa (P <0.05). The IMVD in TP positive group was significantly higher than that in TP negative group (P <0.01) The annual survival rate and overall survival rate were significantly higher than those in the negative TP group (P <0.05). There was no significant difference in the positive rate of TP between high and moderately differentiated cancers in gastric cancer (P> 0.05). Conclusion The expression of TP in gastric cancer is closely related to the angiogenesis in gastric cancer and the prognosis of gastric cancer; it has no relation with the differentiation of gastric cancer