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总结了1990年8月～1995年7月底共50例下肢骨肉瘤区域高温隔离灌注化疗病人，男31例，女19例，年龄平均21岁。肿瘤部位：股骨下端32例，胜骨16例，胖骨2例。隔离灌注化疗60分钟，前11例用顺钻150mg／M2，后39例用卡铂60mg／M2，肿瘤缘深部组织温度保持在42℃。结果：全部患者灌往后局部肿胀明显减退，肿块收缩，质地变硬，二周内患肢周径减少，关节活动度增加。病理检查，瘤体坏死率达90～95％。药物不良反应有术后轻度的胃肠道反应，前11例顺铂病人中1例并发急性肾衰，作者认为，卡铂是区域高温隔离灌注化疗的首选药物之一。
A total of 50 cases of high-temperature isolated infusion chemotherapy in the lower extremity osteosarcoma region from August 1990 to the end of July 1995 were summarized. There were 31 males and 19 females, with an average age of 21 years. Tumor site: 32 cases of lower femur, 16 cases of sacrum, 2 cases of fat bone. After 60 minutes of isolation and infusion chemotherapy, the first 11 cases were treated with 150 mg/M2 cisplatin, and the latter 39 cases were treated with carboplatin 60 mg/M2. The temperature of the deep tissue of the tumor margin was maintained at 42°C. RESULTS: After local irrigation, the local swelling was significantly decreased in all patients. The mass contracted and the texture hardened. The circumference of the affected limb decreased within two weeks and the range of motion of the joint increased. Pathological examination, tumor necrosis rate of 90 to 95%. Adverse drug reactions had mild postoperative gastrointestinal reactions. In the first 11 cases of cisplatin patients, 1 patient had acute renal failure. The authors believe that carboplatin is one of the first choice drugs for high-temperature isolated infusion chemotherapy.