由于下列原因血管紧张素转换酶(ACE)抑制剂的药代动力学难于估计。首先,这些药物发挥作用是通过抑制一系列酶事件中的中间酶,但其中限速酶(肾素)并不直接受ACE 抑制的作用。其次,在 ACE 抑制时肾素与血管紧张素Ⅰ积累,ACE 抑制剂剂量改变可引起血管紧张素Ⅰ突然转为血管紧张素Ⅱ。其三,循环中肾素系统的成分需要几个器官系统和作用部位间的相互作用。其四,ACE 抑制剂的动力学可受负责药物吸收、代谢和排泄的器官系统的影响,而这些系统的 The pharmacokinetics of angiotensin converting enzyme (ACE) inhibitors are difficult to estimate for the following reasons. First, these drugs work by inhibiting intermediate enzymes in a range of enzyme events, but the rate-limiting enzyme (renin) is not directly affected by ACE inhibition. Second, renin and angiotensin I accumulation during ACE inhibition, and changes in ACE inhibitor dosage resulted in a sudden switch of angiotensin I to angiotensin II. Third, the composition of the renin system in the circulation requires the interaction of several organ systems with the site of action. Fourth, the kinetics of ACE inhibitors can be influenced by organ systems responsible for the absorption, metabolism and excretion of drugs,