论文部分内容阅读
[目的]探讨河南省贲门腺癌(GCA)高/低发区肿瘤家族史情况及其与GCA发病风险、性别和发病年龄的关系。[方法]采用问卷调查方法,记录患者一般情况和肿瘤家族史。2633例GCA患者均经病理诊断证实为贲门腺癌;对照组4312例患者均经内镜检查,排除早期GCA和其他上消化道肿瘤。[结果]河南GCA高发区GCA患者家族史阳性率高于对照组(35%vs21%,P=0.00,OR=2.067,95%CI:1.715～2.491);河南GCA低发区GCA患者家族史阳性率也高于对照组(19%vs5%,P=0.00,OR=4.158,95%CI:3.647～5.597)。河南GCA高发区GCA小年龄组(≤50岁)患者家族史阳性率高于大年龄组(≥71岁)(38%vs23%,P=0.01)。[结论]河南GCA高/低发区肿瘤家族史阳性者贲门癌发病风险明显高于阴性者。提示遗传因素在贲门癌发生中可能起重要作用。
[Objective] To investigate the family history of tumor in GCA high / low incidence area and its relationship with the risk of GCA, sex and age of onset. [Methods] The method of questionnaire was used to record the general situation of patients and the family history of tumors. 2633 cases of GCA confirmed by pathological diagnosis of gastric cardia adenocarcinoma; control group of 4312 patients were endoscopic examination, excluding early GCA and other upper gastrointestinal tumors. [Results] The positive rate of family history of GCA patients in GCA high incidence area was higher than that of control group (35% vs 21%, P = 0.00, OR = 2.067, 95% CI: 1.715-2.491) Rates were also higher in the control group (19% vs 5%, P = 0.00, OR = 4.158, 95% CI: 3.647-5.597). The positive rate of family history of GCA patients (≤50 years old) in Henan GCA high incidence area was higher than that of the large age group (≥71 years old) (38% vs23%, P = 0.01). [Conclusion] The family history of GCA in high / low incidence area of Henan province is significantly higher than that of negative ones in the incidence of cardia cancer. Tip genetic factors in cardia cancer may play an important role.