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作者对12例活组织检查证实为慢性活动性丙型肝炎患者(男性10人,女性2人;平均年龄33岁,年龄范围为19～62岁)评价了每天连续注射α干扰素的效力。用轻便的注射泵连续皮下注射900万单位(MU)重组α干扰素2A(rIFN-α2A),注射28天,每天24小时。治疗1周后,见到平均血清丙氨酸转氨酶(ALT)水平有明显减低(P<0.01)(96IU/L;范围58～263),而治疗前ALT(188IU/L,范围119～670)。到第4周仅有4例患者的ALT正常。中止治疗时,在所有患者中见到ALT增加(治疗前1.5～5倍)。ALT的最大量减少与酶2′,5′寡腺苷酸(2—5A)合成酶的血清水
The authors evaluated the efficacy of continuous daily administration of interferon alfa in 12 patients with chronic active hepatitis C confirmed by biopsy (10 males and 2 females; mean age, 33 years, range, ages 19-62 years). Nine million units (MU) of recombinant interferon alpha 2A (rIFN-α2A) were injected subcutaneously, with a light syringe pump, for 28 days and 24 hours a day. After 1 week of treatment, mean serum ALT levels were significantly lower (P <0.01) (96 IU / L; range, 58 to 263), whereas ALT (188 IU / L range, 119-670) . Only 4 patients had normal ALT by week 4. When discontinuation of treatment, an increase in ALT was seen in all patients (1.5 to 5 times before treatment). The maximum amount of ALT is reduced with the serum of the enzyme 2 ’, 5’ oligoadenylate (2-5A) synthase