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目的基于近似熵与相对功率谱对微波辐射后猕猴脑电图进行分析,探讨应用近似熵衡量微波辐射对脑损伤程度的可行性。方法雄性猕猴15只,根据平均功率密度不同,随机分为假辐射组、2 mW/cm2、5 mW/cm2、7 mW/cm2、11 mW/cm2微波辐射组,采用BIOPAC公司生产的MP-150多导生理记录及分析系统,分别于辐射前及辐射后即刻、1 d、3 d、7 d、14 d和30 d,对猕猴脑电图(EEG)近似熵和δ、β频段相对功率谱进行检测。结果 (1)7 mW/cm2组近似熵于辐射后即刻明显下降,11 mW/cm2组近似熵于辐射后即刻、1 d和3 d明显下降。(2)7 mW/cm2组于辐射后即刻,δ频段相对功率谱显著升高,β频段相对功率谱明显下降;11 mW/cm2组于辐射后即刻、1 d和3 d,δ频段相对功率谱显著升高,而β频段相对功率谱则明显下降。(3)2 mW/cm2和5 mW/cm2组近似熵与相对功率谱于辐射后各时间点均未见明显变化。结论 (1)7 mW/cm2和11 mW/cm2微波辐射可引起猕猴脑电生理功能损伤,且与辐射剂量相关;(2)近似熵可客观反映微波辐射对脑功能的损伤,对其进行监测和预测,可望成为一个新的评价微波对脑损伤的敏感指标。
Objective To analyze the EEG of macaques after microwave radiation based on approximate entropy and relative power spectrum, and to explore the feasibility of using microwave to estimate the extent of brain injury by using approximate entropy. Methods Fifteen male rhesus monkeys were randomly divided into 2 groups: radiation group, 2 mW / cm 2, 5 mW / cm 2, 7 mW / cm 2 and 11 mW / cm 2 microwave irradiation group respectively according to the average power density. BIOPAC MP-150 Multi-channel physiological recording and analysis systems were used to measure the approximate entropy and the relative power spectra of the EEG and the δ, β bands in the macaque electroencephalogram (EEG) before and at 1, 3, 7, 14 and 30 d Test. Results (1) The approximate entropy of 7 mW / cm2 group decreased significantly immediately after irradiation, and the approximate entropy of 11 mW / cm2 group decreased immediately after irradiation and decreased significantly on the 1st and 3rd day. (2) At 7 mW / cm2, the relative power spectrum of δ band increased significantly and the relative power spectrum of β band decreased obviously immediately after irradiation. The relative power of δ band at 11 mW / cm2 immediately after irradiation, 1 d and 3 d, Spectrum significantly increased, while the relative power spectrum of β-band decreased significantly. (3) The approximate entropy and relative power spectrum of 2 mW / cm2 and 5 mW / cm2 groups showed no significant changes at all time points after irradiation. Conclusions (1) The microwave radiation of 7 mW / cm 2 and 11 mW / cm 2 can cause the damage of cerebral electrophysiological function in macaque monkey, and it is related to the radiation dose. (2) The approximate entropy can objectively reflect the damage of brain function by microwave radiation and monitor And predict, is expected to become a new evaluation of microwave sensitive indicators of brain damage.