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目的探讨丙型肝炎病毒(HCV)RNA检测在HCV单独感染和HCV、乙型肝炎病毒(HBV)合并感染中的临床意义。方法对96例HCV感染者分别分为CH和LC组,HCV和HCV+HBV组,检测抗-HCV、HCV RNA。结果 96例HCV感染患者中肝硬化组HCV RNA阳性率较慢性肝炎组差异无统计学意义。乙肝和丙肝二重感染者HCV RNA阳性率显著高于单纯HCV感染(χ2=5.65,P=0.017)。单纯HCV感染者和乙肝及丙肝二重感染者血清丙肝病毒含量差异有统计学意义(χ2=5.134,P=0.023)。结论在HCV RNA检测的同时结合HBV DNA的检测,对HCV感染的临床诊治有重要的指导意义。
Objective To investigate the clinical significance of detection of hepatitis C virus (HCV) RNA in HCV infection and hepatitis C virus (HBV) infection. Methods 96 cases of HCV infection were divided into CH and LC groups, HCV and HCV + HBV group, anti-HCV and HCV RNA were detected. Results There was no significant difference in the positive rate of HCV RNA between cirrhosis and chronic hepatitis among the 96 HCV-infected patients. The positive rates of HCV RNA in patients with hepatitis B and C infection were significantly higher than those with HCV infection (χ2 = 5.65, P = 0.017). There was significant difference in the serum hepatitis C virus level between patients with HCV infection and hepatitis B and C infection (χ2 = 5.134, P = 0.023). Conclusions The detection of HCV RNA combined with the detection of HBV DNA has an important guiding significance for the clinical diagnosis and treatment of HCV infection.