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目的:通过芪参安神胶囊主要药效学研究,为临床应用提供实验依据。方法:采用戊巴比妥钠阈下睡眠、避暗试验及强迫游泳时间,分别考查芪参安神胶囊对正常小鼠和去势小鼠的睡眠时间、学习记忆障碍及耐力的影响。结果芪参安神胶囊中、高剂量组对戊巴比妥钠催眠小鼠时间、避暗的潜伏期及电击次数有显著差异(p<0.05,p<0.01);可提高去势小鼠各剂量组的负重游泳时间(p<0.05)。结论:芪参安神胶囊能增加正常小鼠和去势小鼠的睡眠时间,提高去势小鼠耐力,增强记忆功能。
OBJECTIVE: To provide experimental basis for clinical application through the main pharmacodynamic study of Qishen Anshen Capsule. Methods: By using pentobarbital sodium subliminal sleep, dark avoidance test and forced swimming time, the effects of Qishen Anshen Capsule on sleep time, learning and memory impairment and endurance in normal mice and castrated mice were investigated. Results Shenqi Capsule and Qiganshen Shen Capsule showed significant differences in the time of hypnotic mice, the latency to avoid darkness and the number of electric shocks (p <0.05, p <0.01) Of weight-bearing swimming time (p <0.05). Conclusion: Qishen Anshen Capsule can increase the sleep time of normal mice and castrated mice, improve endurance of ovariectomized mice and enhance memory function.