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目的观察盐酸丁咯地尔治疗老年急性脑梗死的临床疗效。方法选择发病48h内的老年急性脑梗死患者85例,随机分为A组44例和B组41例。A组在常规治疗的基础上加用盐酸丁咯地尔200mg静脉点滴,1次/d,连续14d。B组采用常规治疗。治疗前后对患者进行欧洲卒中评分(ESS)、日常生活能力(ADL)、APACHEII评分及C-反应蛋白(CRP)的测定。结果治疗7d后,A组的各项指标较治疗前差异有统计学意义,其中ESS和ADL有显著升高(P<0.01,P<0.05),APACHEII和CRP有显著下降(P<0.05),A组的ESS和APACHEII,与B组比较有显著差异(P<0.05),在治疗14d后,B组的各项指标才较治疗前出现显著差异,而同期A组的各项指标与B组比较显著均有统计学意义。结论盐酸丁咯地尔能够安全有效地治疗老年急性脑梗死。
Objective To observe the clinical effect of buflomedil hydrochloride in the treatment of senile acute cerebral infarction. Methods Eighty-five elderly patients with acute cerebral infarction within 48 hours after onset were randomly divided into group A (44 cases) and group B (41 cases). A group on the basis of conventional therapy plus Buflomedil hydrochloride 200mg intravenously, 1 time / d, continuous 14d. Group B received routine treatment. The patients were assessed for ESS, ADL, APACHEII scores and C-reactive protein (CRP) before and after treatment. Results After treatment for 7 days, the indexes in group A were significantly different from those before treatment. ESS and ADL were significantly increased (P <0.01, P <0.05), and APACHEII and CRP were significantly decreased (P <0.05) A group of ESS and APACHEII, compared with the B group were significantly different (P <0.05), after 14 days of treatment, the B group of indicators before treatment were significantly different, while the same period A group of indicators and B group More significant were statistically significant. Conclusion Buflomedil hydrochloride can safely and effectively treat elderly acute cerebral infarction.