患者,男,37岁。以间断双下肢浮肿2年11个月余为主诉,于2014年5月10日入院,临床诊断为肾病综合征。既往无药物过敏史。患者2011年6月中旬无明显诱因出现双下肢浮肿,休息后无好转,时无上呼吸道感染、发热、无腹痛关节痛、无尿频尿急尿痛及尿色异常,无皮肤红斑及散在出血点,至当地医院查尿蛋白(+++),余检查不详,以肾病综合征为诊断未予治疗,后至某区区医院就诊,患者拒绝行肾穿刺活检术,给 Patient, male, 37 years old. To intermittent edema of lower extremities two years more than 11 months as the chief complaint, admitted on May 10, 2014, the clinical diagnosis of nephrotic syndrome. Past history of drug allergy. Patients in mid-June 2011 no obvious incentive to appear double lower extremity edema, no improvement after rest, no upper respiratory tract infection, fever, no abdominal pain joint pain, urinary frequency of urgency and dysuria urinary abnormalities, no skin erythema and scattered bleeding point , To the local hospital check urinary protein (+++), I check unknown, no diagnosis of nephrotic syndrome was treated, to a district hospital, the patient refused to perform renal biopsy, to