目的探讨海南山苦茶提取物对衰老小鼠学习记忆能力的影响。方法颈背部皮下注射D-半乳糖120mg/kg,连续8周,建立衰老模型,预防性给予海南山苦茶提取物低、中、高剂量(40mg/kg、57mg/kg、81mg/kg)干预,水迷宫、跳台实验和避暗实验测试衰老小鼠的学习记忆能力。结果海南山苦茶提取物能够缩短D-半乳糖诱导的衰老小鼠在水迷宫实验中潜伏期、增加跨越平台次数,延长跳台和避暗实验中的训练和测验潜伏期、减少错误次数,且呈现剂量依赖性。结论海南山苦茶提取物能够改善D-半乳糖诱导的衰老小鼠学习记忆能力。 Objective To investigate the effect of the extract of Shancha bitter tea on learning and memory ability of senile mice. Methods Dose of D-galactose (120mg / kg) was injected subcutaneously into the neck of the neck for 8 weeks. The aging model was established and the low, medium and high dose of 40 mg / kg, 57 mg / kg and 81 mg / , Water maze, jumping test and darkness test to test the learning and memory ability of aged mice. Results Hainan mountain bitter tea extract can shorten the latency of D-galactose-induced aging mice in water maze test, increase the number of platforms across the platform, extend the training and test incubation period in jumping and avoiding experiments, reduce the number of errors, and present the dose Dependency. Conclusion Hainan mountain bitter tea extract can improve D-galactose-induced learning and memory in aging mice.