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酚妥拉明为α-受体阻滞剂,能扩张周围血管。改善微循环,主要用于治疗高血压危象,休克及外周血管痉挛性疾病。近年来,酚妥拉明的临床应用范围越来越广泛,本文主要就其在消化系统疾病中的临床应用概况综述如下: 一、治疗门脉高压上消化道出血:肝硬化门脉高压的发病机制尚未完全被阐明,最近有人发现肝内血管床阻力增加是门脉高压的主要原因,只有通过降低肝内血管阻力,才能有效地降低门脉压。动物实验表明,肝脏门脉血管调节以α-受体为主,α-受体阻滞剂酚
Phentolamine is an alpha-blocker that dilates peripheral blood vessels. Improve microcirculation, mainly for the treatment of hypertensive crisis, shock and peripheral vasospastic diseases. In recent years, the clinical application of phentolamine is more and more widely, this article mainly on its clinical application in the digestive system disease are summarized as follows: First, the treatment of portal hypertension upper gastrointestinal bleeding: the incidence of cirrhosis and portal hypertension Mechanism has not yet been fully elucidated. Recently, it has been found that intrahepatic vascular bed increased resistance is the main cause of portal hypertension, and only by reducing intrahepatic vascular resistance, can effectively reduce the portal pressure. Animal experiments show that the regulation of hepatic portal blood vessels mainly α-receptor, α-blocker phenol