颅内静脉和静脉窦血栓形成(cerebral venous and sinus thrombosis,CVST)最初于1825年由Ribes描述,当时及以后相当一段时间,文献报道多为尸检结果。对其也仅局限于降颅压、抗癫痫等对症治疗,这些对轻型病例有效,而重症患者病死率高。1942年,Lyons描述系统性抗凝治疗CVST,抗凝虽可阻止病情恶化或改善病情,但不能溶解已形成的 Cerebral venous and sinus thrombosis (CVST) was first described by Ribes in 1825, and most of the literature reported at that time and later was autopsy results. It is also limited to reducing intracranial pressure, anti-epilepsy and other symptomatic treatment, which is effective in light cases, and critically ill patients with high mortality. In 1942, Lyons described the systemic anticoagulant therapy CVST, although anticoagulation can prevent the disease from worsening or improve the condition, but can not dissolve the formed