Hepatocellular carcinoma(HCC) is the fifth most common cancer in the world.This case documents an unusual metastatic presentation of HCC in the humerus.Preoperative palliative arterial embolization of the tumor was performed to arrest severe tumor bleeding caused by the biopsy.Embolization turned out to be useful also in limiting/preventing potential uncontrolled bleeding during subsequent amputation. Hepatocellular carcinoma(HCC) is the fifth most common cancer in the world.This case documents an unusual metastatic presentation of HCC in the humerus.Preoperative palliative arterial embolization of the tumor was performed to the incidence of an acute tumor invasion tumor caused by the biopsy.Embolization turned out To be useful also in limiting/preventing potential uncontrolled in the subsequent amputation.