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探讨乙型肝炎病毒不同复制程度对肝纤维化进程的作用。173例乙型肝炎患者分为 6组 :慢性肝炎轻、中、重度 3组 ,肝硬化Child -PughA、B、C级 3组 ;采用放射免疫分析法测定慢性乙型肝炎、肝硬化患者血清IL - 6、IL - 8、PⅢP、c -Ⅳ含量 ,并同时测定HBV -DNA ,按其阳性、阴性进行分组比较。当HBV -DNA(+)时与HBV -DNA(- )时 ,血清IL - 6、IL - 8、PⅢP、c -Ⅳ含量相比较 ,除在轻度组、C级组无显著差异外 (P >0 .0 5 ) ,其余 4组皆有统计学意义 ,以重度组、A级组为著 (P <0 .0 1)。提示 :乙型肝炎病毒活跃复制可促进肝星状细胞的活化 ,从而在肝纤维化的起始、持续发展过程中具有重要作用
To investigate the effect of different degrees of replication of hepatitis B virus on the progress of liver fibrosis. 173 patients with hepatitis B were divided into 6 groups: light, moderate and severe chronic hepatitis group 3, cirrhosis Child-Pugh, B, C grade 3 group; radioimmunoassay was used to detect serum hepatitis B in patients with chronic hepatitis B, cirrhosis - 6, IL - 8, PⅢP and c - Ⅳ, and HBV - DNA were determined at the same time. The levels of IL - 6, IL - 8, PⅢP and c - Ⅳ in serum of patients with HBV - DNA (+) were significantly higher than those of patients with mild hepatitis B > 0. 05). The other four groups were statistically significant, with severe group and A group (P <0.01). Hint: Active replication of hepatitis B can promote the activation of hepatic stellate cells, which play an important role in the initiation and continuous development of hepatic fibrosis