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一般认为早产儿的周期性呼吸和呼吸暂停密切相关。我们认为早产儿周期性呼吸依赖于外周化学感受器的功能,同样呼吸暂停的终止和缩短发作时间也依赖于外周化感器的功能。本文的目的是确定周期性呼吸引起呼吸暂停的机率,以及生后出现周期性呼吸和呼吸暂停的自然规律。资料与方法选择观察的新生儿胎龄小于34周,无明显呼吸道疾病、败血症、电解质紊乱和血糖失调,均做颅脑B超以排除颅内病变。在68名新生儿中,56名临床怀疑有呼吸暂停,定为晚期监护组;另12名于生后12小时内无呼吸停暂指征,定为早期监护组。两组均未用药物和呼吸机所有的新生儿均行心率、肺阻抗图、终未潮气二氧化碳和经皮血氧分压持续监护,由计算机化的资料检索记录,再由半自动分析仪分析。
Periodic respiration and apnea are generally believed to be closely related to preterm infants. We believe that cyclical respiration in preterm infants depends on peripheral chemoreceptor functions, and the same termination of apnea and shortening of seizure times also depend on the function of peripheral sensors. The purpose of this article is to determine the periodicity of breathing-induced apnea and the natural patterns of periodic breathing and apnea after birth. Materials and Methods Selected neonatal gestational age less than 34 weeks, no obvious respiratory disease, sepsis, electrolyte imbalance and blood glucose disorders, are done brain B ultrasound to rule out intracranial lesions. Of the 68 newborns, 56 were clinically suspected of having an apnea and were assigned to an advanced care group. The other 12 were non-apneic temporarily within 12 hours of birth and were assigned to an early care group. Both groups were not monitored by heart rate, lung impedance map, end-tidal carbon dioxide and percutaneous oxygen partial pressure without medicine and ventilator. The computerized data were retrieved and recorded, and analyzed by semi-automatic analyzer.