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采用高效液相色谱法（ＨＰＬＣ）对６名健康志愿者单次静脉注射盐酸劳卡尼的药代动力学进行了研究。剂量为１．０ｍｇ／ｋｇ。血药浓度－时间数据按３Ｐ８７程序进行拟合，符合静注二室开放模型。给药后１ｍｉｎ血药浓度为２１８．３５±５１．４０μｇ／Ｌ。主要药代动力学参数Ａ（Ｃｏ）为２５９．２±２１３．４μｇ／Ｌ；Ｖ为２３５．９±１１６．９Ｌ；ｔ１／２β为４．０５２±２．９３９ｈ；ＣＬ为１１９．７±９２．２３Ｌ／ｈ；ＡＵＣ为６７５．９±３９３．１（μｇ·ｈ）／Ｌ。
The pharmacokinetics of a single intravenous injection of raccoal hydrochloride in six healthy volunteers was studied by high performance liquid chromatography (HPLC). The dose is 1.0 mg / kg. Plasma concentration - time data according to 3P87 program fitting, in line with intravenous infusion of two open model. 1min after administration of plasma concentration of 218.35 ± 51.40μg / L. The main pharmacokinetic parameters A (Co) were 259.2 ± 213.4 μg / L; V was 235.9 ± 116.9 L; t1 / 2β was 4.052 ± 2.939 h; CL was 119.7 ± 92 .23 L / h; AUC was 675.9 ± 393.1 (μg · h) / L.