Purpose: Memantine, an uncompetitive NMDA receptor channel blocker has been used in the treatment of Parkinson’s disease and dementia. This study was done to evaluate the neu-roprotective effeet of memantine in different retinal ganglion cell (RGC) injury models in rats. Methods: Neuroprotective effect of memantine was tested in calibrated optic nerve injury Purpose: Memantine, an uncompetitive NMDA receptor channel blocker has been used in the treatment of Parkinson’s disease and dementia. This study was done to evaluate the neu-roprotective effector of memantine in different retinal ganglion cell (RGC) injury models in rats. Methods: Neuroprotective effect of memantine was tested in calibrated optic nerve injury