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报告2例单纯疱疹性肝炎并发亚急性肝坏死。2例均同时有发热、血清转氨酶明显增高及血白细胞数明显减少。例1为65岁女性,于住院第18天死亡。尸检:肝切片镜检有亚急性肝坏死变化,肝细胞内有嗜酸性内核包涵体。肝切片用免疫过氧化酶染色在肝细胞核内、细胞浆及细胞膜均证实有单纯疱疹病毒抗原,电镜检查证实有疱疹病毒。食道有直径7.5mm 的溃疡,镜检有很多上皮内核包涵体,两侧肾上腺有局灶性皮质坏死。例2为28岁
2 cases of herpes simplex hepatitis complicated with subacute hepatic necrosis. 2 cases both have fever, serum aminotransferase was significantly higher and white blood cell count was significantly reduced. Example 1 A 65-year-old woman died on the 18th day of hospitalization. Autopsy: liver slice microscopy subacute changes in liver necrosis, hepatocyte eosinophilic core inclusion body. Liver slices with immunoperoxidase staining in the liver nuclei, cytoplasm and cell membrane were confirmed with herpes simplex virus antigen, electron microscopy confirmed herpes virus. The esophagus has a diameter of 7.5mm ulcer, microscopic examination of a large number of epithelial nucleus inclusions, adrenal both sides of focal cortical necrosis. Example 2 is 28 years old