前列腺癌预防研究(PCPT)发现,与安慰剂相比,5α还原酶抑制剂非那雄胺在7年内可以显著降低前列腺癌发生率,但非那雄胺组前列腺癌中Gleason评分7～10的肿瘤比例显著增加。作者为了解5α还原酶抑制剂对前列腺癌检测和自然病史的影响,详细检索了Medline的相关文献。在PCPT研究中,非那雄 The Prostate Cancer Prevention Study (PCPT) found that finasteride, a 5α-reductase inhibitor, significantly reduced the incidence of prostate cancer over 7 years compared with placebo, but the Gleason score of 7-10 in the group of patients with finasteride The proportion of tumors increased significantly. In order to understand the effects of 5α-reductase inhibitors on prostate cancer detection and natural history, the authors searched Medline’s articles in detail. In the PCPT study, phenazone