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目的了解吉林省医务人员中乙型肝炎病毒(HBV)感染情况,为在医务人员中有效开展乙型肝炎(乙肝)疫苗免疫策略提供依据。方法本研究包括2 736名在职医务人员及390名退休医务人员,分别来自吉林省某医院(在职医务人员729名,退休医务人员390名)、四平市某医院(在职医务人员1 053名)、公主岭市某医院(在职医务人员954名),采用问卷调查形式收集医务人员基本信息,并用雅培ArchitectI2000分析仪检测HBV表面抗原(HBsAg)、表面抗体(抗-HBs)及核心抗体(抗-HBc)。资料用SPSS13.0软件进行统计分析。结果2 736名在职医务人员中,HBsAg、抗-HBc、抗-HBs阳性率分别为1.39%(38/2 736)、33.44%(915/2 736)和63.49%(1 737/2 736),该3项标志物全阴性者占30.81%(843/2 736)。390名退休医务人员中,HBsAg、抗-HBc和抗-HBs阳性率分别为3.33%(13/390)、61.54%(240/390)和60.77%(237/390),该3项标志物全阴性者占23.33%(91/390)。在不同年龄组的医务人员中,40～50岁和50岁以上年龄组医务人员HBsAg携带率显著高于20～30岁和30～40岁年龄组,抗-HBs阳性率低于20～30岁和30～40岁年龄组。所有医务人员中,随年龄增加,抗-HBc阳性率逐渐上升。辅助科室人员抗-HBs和抗-HBc阳性率较低,分别为52.74%(424/804)和34.08%(274/804),3项标志物全阴性率为39.80%(320/804)。结论吉林省在职医务人员HBsAg携带率和抗-HBc阳性率较低,但3项HBV血清标志物全阴性率高达30.81%,提示这部分医务人员体内无HBV保护性抗体,应接种乙肝疫苗。
Objective To understand the status of hepatitis B virus (HBV) infection among medical staffs in Jilin Province and provide basis for effectively carrying out Hepatitis B (HBV) vaccine immunization strategy among medical staffs. Methods The study included 2 736 active medical staff and 390 retired medical staff from a hospital in Jilin Province (729 active medical staff and 390 retired medical staff), a hospital in Siping City (1,053 active medical staff) A hospital in Gongzhuling City (954 active medical staff) collected medical staff’s basic information by questionnaire, and detected HBsAg, anti-HBs and anti-HBc with Abbott ArchitectI2000 analyzer. . Data SPSS13.0 software for statistical analysis. Results The positive rates of HBsAg, anti-HBc and anti-HBs among 2 736 active medical staff were 1.39% (38/2 736), 33.44% (915/2 736) and 63.49% (1737/2 736), respectively The three markers were all negative accounted for 30.81% (843/2 736). Among the 390 retired medical staff, the positive rates of HBsAg, anti-HBc and anti-HBs were 3.33% (13/390), 61.54% (240/390) and 60.77% (237/390), respectively Negatives accounted for 23.33% (91/390). Among medical staff of different age groups, the HBsAg carrier rate of medical staff aged 40-50 years and over 50 years old was significantly higher than that of 20-30 years old and 30-40 years old group, and the positive rate of anti-HBs was lower than 20-30 years And 30 to 40 age group. All medical staff, with age, anti-HBc positive rate gradually increased. The positive rates of anti-HBs and anti-HBc were lower in auxiliary departments, which were 52.74% (424/804) and 34.08% (274/804), respectively. The negative rates of all three markers were 39.80% (320/804). Conclusion The HBsAg carrier rate and anti-HBc positive rate of serving medical staffs in Jilin Province are low, but the full negative rates of three HBV serum markers are as high as 30.81%, suggesting that some HBsAg carriers should not have HBV protective antibodies and should be vaccinated with Hepatitis B vaccine.