[目的]探讨手足口病的流行病学特征及护理措施。[方法]回顾性分析2009年1月～12月我校附属医院小儿科、感染内科手足口病患者158例的临床资料。[结果]发病年龄以5岁以下多见,占90.5%,男性患儿多于女性;发病高峰为4～7月份;患儿发病前有可疑流行病学接触史及不洁史;临床表现典型,伴有发热,症状轻微,皮疹以手部和足部较多,而疱疹多出现在口腔和手部。针对病情,进行口腔、皮肤、心理等护理,密切观察病情,积极进行健康宣教。[结论]手足口病的发生存在明显季节、性别、年龄差异,早发现、早隔离、早治疗,采取行之有效的护理干预,可预防并发症,降低死亡率。 [Objective] To explore the epidemiological characteristics of hand-foot-mouth disease and nursing measures. [Methods] The clinical data of 158 pediatric patients with hand-foot-mouth disease who were infected in our hospital from January to December 2009 were retrospectively analyzed. [Results] The onset age was more common in children under 5 years old, accounting for 90.5% of all cases. There were more males than females; the peak incidence was from April to July; , Accompanied by fever, mild symptoms, skin rash with more hands and feet, and herpes appear more in the mouth and hands. For the disease, oral, skin, psychological care, close observation of the disease, active health education. [Conclusion] The occurrence of hand, foot and mouth disease is obviously seasonal, gender and age difference. Early detection, early isolation, early treatment and effective nursing intervention can prevent complications and reduce mortality.