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目的观察奥扎格雷钠治疗急性脑梗死的疗效及对血浆溶血磷脂酸(LPA)和酸性磷脂(AP)的影响。方法 72例该病患者随机分为治疗组和对照组,两组均常规应用阿司匹林抗血小板聚集、营养脑细胞、脱水降颅压等对症支持处理,治疗组加用奥扎格雷钠治疗。比较两组治疗前后疗效、神经功能缺损评分及血浆LPA、AP水平。结果治疗组总有效率显著高于对照组(P<0.05)。两组治疗后血浆神经功能缺损评分、LPA、AP较前均显著下降(P<0.05),且治疗后治疗组神经功能缺损评分、LPA、AP均显著低于对照组(P<0.05)。结论奥扎格雷钠治疗急性脑梗死疗效确切,可降低血浆LPA和AP水平。
Objective To observe the therapeutic effect of ozagrel on acute cerebral infarction and its effect on plasma lysophosphatidic acid (LPA) and acid phospholipid (AP). Methods Seventy-two patients were randomly divided into treatment group and control group. Both groups were given conventional anti-platelet aggregation, nutritional brain cells, dehydration and intracranial pressure to treat symptomatic treatment. The treatment group was treated with ozagrel sodium. The curative effect, neurological deficit score and plasma LPA and AP levels were compared between the two groups before and after treatment. Results The total effective rate in the treatment group was significantly higher than that in the control group (P <0.05). After treatment, the plasma neurological deficit score, LPA and AP decreased significantly (P <0.05), and the neurological deficit score, LPA and AP in the treatment group were significantly lower than those in the control group after treatment (P <0.05). Conclusion Ozagrel sodium in the treatment of acute cerebral infarction with exact effect, can reduce plasma LPA and AP levels.