论文部分内容阅读
中性脂肪主要指三酰甘油(triacylglycerol,TAG),是动植物细胞贮脂的主要形式。TAG约占人体脂类的95%,它的合成与动员是能量平衡调节的主要环节,而这一调节的失衡是诱发肥胖,产生高血压、心脏病及皮下脂肪丢失等疾病的主要原因。油脂代谢受到油脂基因所编码的脂肪相关调节酶的直接调控,中性脂肪代谢过程有高度的真核系统保守性。磷脂酸磷酸酶(phosphatidate phosphatase,PAP)也称脂素,相关基因PAH1(酿酒酵母)、LPIN1、LPIN2、LPIN3(哺乳动物)是研究人员近年确定的一类中性脂肪代谢调控的关键基因。相关的研究为进一步了解脂肪代谢有关疾病提供了一个重要线索,并且可能为研发控制脂肪代谢的新药提供新靶点。就近年PAP的相关研究主要成果进行概述。
Neutral fat mainly refers to triacylglycerol (TAG), is the main form of storage of fat in animal and plant cells. TAG accounts for about 95% of the body fat, its synthesis and mobilization is the main part of the regulation of energy balance, and the imbalance of this regulation is the main cause of obesity, hypertension, heart disease and subcutaneous fat loss and other diseases. Oil metabolism is regulated directly by fat-related regulatory enzymes encoded by the oleosin gene, and the neutral fat metabolism is highly conserved in eukaryotic systems. Phosphatidate phosphatase (PAP) also known as lipids, related genes PAH1 (Saccharomyces cerevisiae), LPIN1, LPIN2, LPIN3 (mammalian) researchers identified in recent years a class of neutral fat metabolism regulation key genes. Related research provides an important clue for further understanding of diseases related to fat metabolism and may provide a new target for the development of new drugs that control fat metabolism. In recent years, the main results of PAP related research are summarized.