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目的:观察二甲复肝颗粒联合腹水超滤浓缩回输术治疗肝硬化顽固性腹水的临床疗效。方法:75例患者随机分成2组,对照组予西医常规对症治疗,治疗组在对照组基础上加用二甲复肝颗粒联合腹水超滤浓缩回输术治疗。观察并记录2组患者治疗前后的自觉症状,腹围、体重、尿量等体征,以及血浆白蛋白(Alb)、肾功能[尿素氮(BUN)、肌苷(Cr)]、电解质[钠(Na+)、钾(K+)、氯(Cl-)]等。结果:治疗后2组腹围减少量、消除腹水量、尿量增加量及总有效率分别比较,差异均有显著性意义(P<0.05)。治疗组治疗后Alb、BUN、Cr均明显降低,与治疗前比较,差异均有显著性意义(P<0.05)。结论:二甲复肝颗粒联合腹水超滤浓缩回输术治疗肝硬化顽固性腹水疗效显著,值得推广应用。
OBJECTIVE: To observe the clinical effects of combination of DMH particles and ascites ultrafiltration concentrating and transfusion in the treatment of refractory cirrhosis and ascites. Methods: Seventy-five patients were randomly divided into two groups. The control group was treated with western medicine routine symptomatic treatment. The treatment group was treated with ultrafiltration plus dimethylgallib liver granules combined with ultrafiltration in the control group. The symptoms, abdominal circumference, body weight and urine output were observed and recorded before and after treatment. The levels of serum albumin (Alb), renal function (BUN and creatinine), electrolytes [sodium Na +), potassium (K +), chlorine (Cl-)] and the like. Results: After treatment, the reduction of abdominal circumference, the volume of ascites, the increase of urine volume and the total effective rate of the two groups were significantly different (P <0.05). After treatment, Alb, BUN and Cr in treatment group were significantly lower than those before treatment, the difference was significant (P <0.05). Conclusion: The treatment of refractory ascites caused by liver cirrhosis with combination of Erg-Fugan granule and ultrafiltration concentration and transfusion of ascites has a significant effect and is worth popularizing and applying.