多数非何杰金氏B细胞淋巴瘤含有t(14;18),该易位使bcl2基因进入具有转录活性的Ig重链座位,使这一原癌基因表达失去控制。bcl 2基因产物是膜相关线粒体蛋白,它通过未知机制调节细胞生存。该正常蛋白的超量产生足以使B细胞具备选择性生长优势或生存优势.已有作者报道,在淋巴 Most non-Hodgkin’s B-cell lymphomas contain t (14; 18), which translocates the bcl2 gene into the transcriptionally active Ig heavy chain locus, leaving this proto-oncogene expression out of control. The bcl 2 gene product is a membrane-associated mitochondrial protein that regulates cell survival through unknown mechanisms. The excess production of this normal protein is sufficient for B cells to have a selective growth advantage or survival advantage. The authors have reported that in the lymph