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目的:比较苄星青霉素对妊娠期梅毒感染患者的妊娠结局及其对围生儿梅毒感染疗效的影响。方法:选取2014年10月—2016年10月期间在医院接受治疗的妊娠期梅毒感染患者84例临床资料,依据治疗方式的不同将其分为观察组(52例)和对照组(32例);观察组患者给予苄星青霉素治疗,对照患者给予红霉素治疗,比较两组患者用药后的妊娠结局及其对围生儿梅毒感染的影响。结果:观察组患者用药后早产、胎儿窘迫、流产、死胎、死产和胎膜早破等妊娠结局的发生率为28.08%与对照组为28.13%经组间比较其差异无统计学意义(P>0.05);观察组患者的围生儿梅毒感染的发生率为11.54%与对照组为15.63%经组间比较其差异无统计学意义(P>0.05)。结论:苄星青霉素与红霉素对妊娠期梅毒感染患者的妊娠结局及其对围生儿梅毒感染的疗效无影响,均能改善患者的妊娠结局和围生儿梅毒感染的发生率。
Objective: To compare the effect of penicillin on the pregnancy outcomes of patients with syphilis infection during pregnancy and its effect on perinatal infection with syphilis. Methods: The clinical data of 84 cases of syphilis infection during pregnancy from October 2014 to October 2016 in our hospital were divided into the observation group (52 cases) and the control group (32 cases) according to the different treatment methods. . The patients in the observation group were treated with benzathine penicillin and the control patients were given erythromycin. The pregnancy outcome and the effect on perinatal infection of syphilis were compared between the two groups. Results: The incidence of pregnancy outcomes such as preterm birth, fetal distress, miscarriage, stillbirth, stillbirth and premature rupture of membranes in the observation group was 28.08% compared with 28.13% in the control group. There was no significant difference between the two groups (P > 0.05). The incidence of perinatal syphilis infection was 11.54% in the observation group and 15.63% in the control group. There was no significant difference between the two groups (P> 0.05). Conclusion: There is no effect of penicillin and erythromycin on the pregnancy outcome of patients with syphilis infection during pregnancy and their effect on perinatal infection of syphilis, both of which can improve the pregnancy outcome and the incidence of perinatal syphilis infection.