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目的应用踝臂指数和动脉僵硬度评价高血压病患者和冠心病患者的动脉功能变化。方法 348例受检者入选本研究,其中正常组122例,高血压病组118例,冠心病组108例。所有受检者应用动脉僵硬度和踝臂指数(AB I)对动脉功能进行了评估。结果颈动脉-股动脉的脉搏波速度冠心病组为(11.7±2.5)m/s,与正常组(10.2±1.6)m/s比较,差异有统计学意义(P<0.01);踝-臂脉搏波传导速度冠心病组为(1601±267)cm/s,高血压病组为(1607±311)cm/s,与正常组(1360±209)cm/s比较,差异有统计学意义(P<0.01);AB I冠心病组为1.09±0.14,与高血压组(1.15±0.07)比较,差异有统计学意义(P<0.01)。结论动脉僵硬度能够方便、快捷、无创评价动脉功能和结构的早期变化,高血压病及冠心病患者外周动脉弹性功能明显降低。
Objective To evaluate the changes of arterial function in hypertensive patients and patients with coronary heart disease by using ankle brachial index and arterial stiffness. Methods A total of 348 subjects were enrolled in the study, including 122 normal subjects, 118 hypertensives and 108 coronary heart disease patients. All subjects evaluated arterial function using arterial stiffness and ankle brachial index (ABI). Results The pulse wave velocity of carotid artery-femoral artery in CHD group was (11.7 ± 2.5) m / s, which was significantly different from that in normal group (10.2 ± 1.6) m / s (P <0.01) The pulse wave velocity was (1601 ± 267) cm / s in coronary heart disease group and (1607 ± 311) cm / s in hypertension group, which was significantly different from that in normal group (1360 ± 209 cm / s) P <0.01). The prevalence of coronary heart disease in ABI group was 1.09 ± 0.14, which was significantly higher than that in hypertension group (1.15 ± 0.07) (P <0.01). Conclusion Arterial stiffness can be used as a convenient, rapid and noninvasive method to evaluate early changes of arterial function and structure. The peripheral arterial elasticity of patients with hypertension and coronary heart disease is significantly reduced.