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作者测定了不同胎龄胎儿及成人共13例的肝组织、6例肝癌病人癌组织及小鼠 H_(22) 肝癌组织及腹水癌细胞中的 OCT 活性,发现在人胚肝中 OCT活性随发育而增高,肝癌组织及 H_(22) 肝癌细胞中 OCT 活性显著降低,呈现去分化现象。
The authors measured the OCT activity of liver tissues from 13 fetuses and adults of different gestational ages, 6 cases of liver cancer patients, and H_(22) hepatoma tissues and ascitic cancer cells. It was found that OCT activity in human embryonic liver develops. However, the OCT activity in hepatocellular carcinoma and H_(22) hepatoma cells was significantly reduced and showed dedifferentiation.