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本文报告2例癫痫儿童因丙戊酸钠治疗引起的夜尿症。例1:女孩6岁,发育正常。3岁时即能自控小便。因癫痫小发作一日10～20次,并伴有阵挛动作和自动症,给予丙戊酸钠200mg一日三次,症状明显控制,但用药第二天后每天出现夜尿,清晨血浆丙戊酸钠浓度为52.2μg/ml。将丙戊酸钠减为200mg一日二次(血浆丙戊酸钠浓度33μg/ml)后夜尿消失。例2:女孩,出生3月后即有痉挛发作。有癫痫家族遗传史。曾给予苯巴比妥5mg/kg无明显疗效。患儿3岁半时开始给予丙戊酸钠100mg一日三次,20mg/kg治疗,因用药后第三天出现夜尿而自行停药。患儿3岁时能自控小便。6岁时因服苯巴比妥每日80mg仍癫痫大发作一月1～2次,而再次给予丙戊酸钠一日三次150mg(19mg/kg)。用药后第三天夜尿复发。清晨血浆丙戊酸钠浓度为
This article reports 2 children with epilepsy due to sodium valproate treatment of nocturia. Example 1: Girl 6 years old, normal development. 3 years old that can control the urine. Small seizures due to epileptic 10 to 20 times a day, and accompanied by clonic seizures and auto-medication, given sodium valproate 200mg three times a day, the symptoms were significantly controlled, but the day after the next day of administration of nocturia, morning plasma valproic acid The sodium concentration was 52.2 μg / ml. Nocturia disappeared after reducing sodium valproate to 200 mg twice daily (plasma sodium valproate concentration 33 μg / ml). Example 2: Girl, spasms episode after birth in March. Have a family history of epilepsy. Had given phenobarbital 5mg / kg no significant effect. Children aged 3 years and a half started giving sodium valproate 100mg three times a day, 20mg / kg treatment, due to the third day after treatment of nocturnal and discontinuation of their own. 3 years old children can control the urine. 6-year-old due to phenobarbital 80mg daily epileptic seizures in January 1 or 2 times, and once again given sodium valproate 150mg three times daily (19mg / kg). Nocturia recurred on the third day after treatment. Morning plasma sodium valproate concentration