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为了探讨幽门螺旋杆菌（HeliclbacterPylori，HP）感染与胃癌发生间的关系，我们采用免疫组化法对158例胃粘膜标本进行癌基因c－myc、c－erbB－2蛋白检测、其中胃癌、不典型增生及肠上皮化生各40例，正常对照38例。结果发现，c－myc蛋白在正常胃组织中无表过，c－erbB－2蛋白阳性表达7／38例。两种基因蛋白在不典型增生、肠上皮化生及胃癌中的阳性表达显著高于对照组（P＜0．01～0．05）。应用Giemsa法对上述各组胃粘膜同步进行HP测定，发现正常对照组中的HP阳性检出显著低于不典型增生及肠上皮化生（P＜0．025），而与胃癌组无明显统计学差异（P＞0．05）。联合检测HP与癌基因蛋白发现HP感染与其表达呈正相关。提示HP感染与胃癌发生有一定关系。
In order to investigate the relationship between Helicobacter pylori (HP) infection and the occurrence of gastric cancer, 158 cases of gastric mucosa were examined for c-myc and c-erbB-2 oncogene by immunohistochemistry. Among them, gastric cancer, atypical 40 cases of hyperplasia and intestinal metaplasia, 38 cases of normal control. The results showed that c-myc protein in normal gastric tissue without the table, c-erbB-2 protein expression was 7/38 cases. The positive rates of the two genes in dysplasia, intestinal metaplasia and gastric cancer were significantly higher than those in the control group (P <0.01 ~ 0.05). The Giemsa method was used to measure the gastric mucosal synapse in all the above groups. It was found that the positive rate of HP in the normal control group was significantly lower than that in the atypical hyperplasia and intestinal metaplasia (P <0.025), but not with the gastric cancer group Learning difference (P> 0.05). Combined detection of HP and oncoprotein revealed that HP infection was positively correlated with its expression. Tip HP infection and gastric cancer have a certain relationship.