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目的探讨琥珀酸美托洛尔对有心脏症状更年期综合征患者疗效的影响。方法 67例更年期综合征妇女且有心脏症状患者,排除其他器质性心脏病变,随机分为琥珀酸美托洛尔组(36例)和对照组(31例),所有患者给予谷维素20 mg(3次/d)治疗,琥珀酸美托洛尔组给予美托洛尔治疗,初始剂量为47.5 mg(1次/d)。治疗前后所有患者均行24小时动态心电图检查。随访4周,治疗结束时评估两组患者疗效。结果治疗后琥珀酸美托洛尔组患者心率变异性及临床症状明显改善,且改善程度优于对照组,差异有统计学意义(P<0.05)。结论琥珀酸美托洛尔能有效改善有心脏症状更年期综合征患者的症状。
Objective To investigate the effect of metoprolol succinate on the efficacy of menopausal syndrome patients with cardiac symptoms. Methods 67 cases of climacteric syndrome women and patients with cardiac symptoms, excluding other organic heart disease were randomly divided into metoprolol succinate group (36 cases) and control group (31 cases), all patients were given oryzanol 20 mg ( 3 times / d) metoprolol succinate group metoprolol treatment, the initial dose of 47.5 mg (1 / d). Before and after treatment, all patients underwent 24-hour Holter examination. Follow-up 4 weeks, the end of treatment to assess the efficacy of two groups of patients. Results The heart rate variability and clinical symptoms of Metoprolol succinate group were significantly improved after treatment, and the improvement was better than that of the control group (P <0.05). Conclusion Metoprolol succinate can effectively improve the symptoms of menopausal syndrome patients with cardiac symptoms.