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目的研究内源性生长因子含量变化对创伤修复结局的影响。方法用放射免疫和改进的 Cortas 法测定34例瘢痕和肉芽创面组织匀浆中 EGF、TNF 和 NO 含量变化,并探讨这三种因子含量变化与组织修复效果的关系。结果以上三种因子含量在瘢痕组织显著高于溃疡创面肉芽组织,其中以男性或青少年以及伤后1～2年患者的标本更为明显。结论创面内源性生长因子含量不足或过多分别是溃疡形成与瘢痕生长的原因之一。
Objective To study the effect of changes of endogenous growth factor on wound healing outcome. Methods The radioimmunoassay and modified Cortas method were used to determine the content of EGF, TNF and NO in 34 cases of scar and granulation wound tissue homogenate. The relationship between the changes of these three factors and the effect of tissue repair was discussed. Results The above three factors in the scar tissue were significantly higher than those in the ulcer wound granulation tissue, especially in male or adolescent patients and in patients 1-2 years after injury. Conclusion Insufficient or excessive endogenous growth factor in the wound surface is one of the causes of ulcer formation and scar growth respectively.