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大脑老化是神经退行性疾病的主要诱因。而卒中不仅是老年人的神经系统常见疾病,而且也是70岁以上老年人致残和死亡的重要原因,因此,大脑老化与卒中发病息息相关。已经证实,老年卒中患者其缺血性脑组织损伤更加严重、脑梗死面积更大、缺血后的神经功能障碍也更加显著。尽管研究已证实老龄大脑的神经再生减少,但卒中可以诱导神经再生并能有效促进神经功能恢复,这就为神经再生治疗卒中开辟了良好的途径。本文重点就大脑老化及老化后神经再生、缺血性卒中作一简要综述。
Brain aging is a major cause of neurodegenerative diseases. Stroke is not only a common disease of the nervous system of the elderly, but also an important cause of disability and death in the elderly over 70 years old. Therefore, aging of the brain is closely related to the incidence of stroke. It has been confirmed that elderly stroke patients have more severe ischemic brain damage, a larger area of cerebral infarction, ischemic neurological dysfunction is also more pronounced. Although studies have shown that the regeneration of the aged brain is reduced, stroke can induce the regeneration of the nerve and effectively promote the recovery of the nerve function, which opens up a good way for the treatment of stroke. This article focuses on brain aging and aging after nerve regeneration, a brief review of ischemic stroke.