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目的:研究阿帕替尼治疗晚期胃癌的临床疗效。方法:选取我院肿瘤科2015年3月到2016年3月期间接诊的50例晚期胃癌患者,患者均为经根治性切除术后复发或转移,或病期晚无法耐受手术治疗。患者均严格给予阿帕替尼单药口服治疗,服药一个月后评估病情。评估患者的临床症状和肿瘤缓解情况。结果:全组患者中,症状完全缓解0例,症状明显缓解10例,症状部分缓解20例,症状稳定17例,症状加重3例,症状缓解有效率60.0%,(p<0.05)。影像学检查显示全组患者转移灶缩小15例,稳定27例,疾病控制率84%。结论:阿帕替尼单药治疗晚期胃癌疗效较好,同时能显著改善患者临床症状。
Objective: To study the clinical efficacy of apatinib in the treatment of advanced gastric cancer. Methods: Fifty patients with advanced gastric cancer admitted from March 2015 to March 2016 in our department of oncology were recruited or treated by radical resection. Patients were given single oral administration of apatinib, one month after taking the drug to assess the condition. Assess patient’s clinical symptoms and tumor response. Results: In all the patients, the symptoms were completely relieved in 0 cases, the symptoms were relieved in 10 cases, the symptoms were partly relieved in 20 cases, the symptoms were stable in 17 cases, the symptoms were aggravated in 3 cases, and the symptom relief rate was 60.0% (p <0.05). Radiographic examination showed that the metastasis in all patients was reduced in 15 cases, stable in 27 cases, disease control rate of 84%. Conclusion: Apatinib monotherapy for the treatment of advanced gastric cancer is better, and can significantly improve the clinical symptoms of patients.