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目的 :研究调胃丸的治疗机制及药理作用。方法 :采用幽门弹簧扩张法及胃部胆汁与小肠液灌注法引起小鼠的慢性胆汁反流性胃炎和急性胃炎后给予不同剂量调胃丸治疗 ,观察其疗效。结果 :调胃丸能减少小鼠胃粘膜出血点 ,减轻粘膜水肿 ,抑制反流性胃炎的发生率 ,尤以大剂量作用明显 ,与模型组比较有极显著性差异 (P <0 .0 1) ;并对醋酸引起的小鼠扭体反应有一定的抑制作用。结论 :调胃丸有一定的镇痛作用 ,对急、慢性反流性胃炎均有一定的保护作用。
Objective: To study the therapeutic mechanism and pharmacological effects of Tiaowan Pills. METHODS: Different doses of Tiaowan Pills were administered to mice with chronic bile-regurgitational gastritis and acute gastritis induced by pyloric spring expansion and gastric bile and intestinal perfusion to observe its efficacy. Results: Tiaowan Pill can reduce gastric mucosal bleeding in mice, reduce mucosal edema, and inhibit the incidence of reflux gastritis, especially with large doses, and there is a significant difference compared with the model group (P < 0.01). ); And acetic acid-induced writhing in mice have a certain degree of inhibition. Conclusion : Tiaowan Pill has a certain degree of analgesic effect and protects both acute and chronic reflux gastritis.