Notch信号是一种进化保守性细胞间的相互作用机制,可影响发育过程中多种细胞的分化、增殖和凋亡,进而决定细胞命运和发育过程,在多种组织和器官的早期发育过程中起中心作用。近年来,有关Notch信号通路在胚胎肺发育发生中的作用已成为国际研究热点。本文就Notch信号的基因结构及 Notch signaling is an evolutionarily conserved cell-cell interaction mechanism that affects the differentiation, proliferation and apoptosis of a wide variety of cells during development, which in turn determines the cell’s fate and development, during the early development of various tissues and organs Play a central role. In recent years, the role of Notch signaling pathway in embryonic lung development has become an international research hotspot. In this paper, Notch signal gene structure and