目的:通过对全国药品不良反应监测网络数据库2011年上半年上海市宝山区头孢呋辛不良反应的分析,了解其安全性,以指导临床合理用药。方法:以头孢呋辛为关键词,系统查询2011年上半年全国药品不良反应监测网络上海市宝山区数据库;对检索到的病例报告不良反应及合理用药情况进行分析。结果:共检索到144例头孢呋辛引起的不良反应/事件;不良反应/事件中存在不合理用药现象。结论:临床在使用头孢呋辛时,存在较多不合理用药现象;合理使用头孢呋辛可以降低其风险,提高安全性。 OBJECTIVE: To analyze the adverse reactions of cefuroxime in Baoshan District of Shanghai in the first half of 2011 through the database of National Adverse Drug Reaction Monitoring Network to understand its safety and to guide clinical rational drug use. Methods: Taking cefuroxime as the key word, the system inquired about the national database of adverse drug reaction monitoring network in Baoshan District, Shanghai in the first half of 2011, and analyzed the reported adverse reactions and rational drug use cases. Results: A total of 144 cases of cefuroxime-induced adverse reactions / events were detected. There was an irrational use of drugs in adverse reactions / events. Conclusion: There is more irrational drug use in clinical use of cefuroxime. The rational use of cefuroxime can reduce the risk and improve the safety.