作者认为发热性皮肤粘膜综合征,约可分为两类型:(1)多口糜烂外胚叶病(Stevns-Johnson综合征);(2)中毒性表皮坏死松解症(Lyell综合征)。前者有40～80％,后者有80～90％都是由药物引起,并且两者都可能是由于感染病原体而发生。前者的死亡率大概占5～15％;后者则占5～52％。药物诱发这两种综合征的,磺胺剂和抗菌素居首位,其次为止痛退热剂、巴比妥酸盐和抗癫痫剂。引起前者的病原体是肺炎支原体(Mycoplasmapneumoniae)、人疱疹病毒、链球菌、沙门氏菌;引起后者的病原体是葡萄球菌。作者回顾了自1964年至1972年瑞典药物管理处 The authors believe that febrile mucocutaneous syndrome, can be divided into two types: (1) multi-erosive ectodermal disease (Stevns-Johnson syndrome); (2) toxic epidermal necrolysis (Lyell’s syndrome). The former has 40 to 80%, the latter 80 to 90% are caused by the drug, and both may be due to infection pathogens occur. The former’s mortality rate accounts for about 5 to 15%; the latter accounts for 5 to 52%. Drug-induced these two syndromes, sulfa drugs and antibiotics in the first place, followed by pain relief fever, barbiturates and antiepileptic agents. The pathogens causing the former are Mycoplasma pneumoniae, human herpesvirus, streptococcus and salmonella; the pathogen causing the latter is staphylococcus. The authors reviewed the Swedish Drug Administration from 1964 to 1972