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目的研究铁调素和膜转铁蛋白(FPN)在胃癌组织中的表达及其临床意义。方法应用免疫组化染色法检测62例胃癌组织和15例癌旁正常胃黏膜组织中铁调素和FPN的蛋白表达,分析其与临床病理特征的关系。结果与癌旁正常胃黏膜组织相比,胃癌组织中铁调素阳性表达率增加(56.5%vs.20.0%)(P<0.05),而FPN阳性表达率减少(54.8%vs.80.0%)(P<0.05)。铁调素和FPN表达均与TNM分期有关(P<0.05),而与年龄、性别、淋巴结转移、远处转移及贫血无关(P>0.05)。铁调素与FPN表达呈负相关(r=-0.27,P<0.05)。结论胃癌组织高表达铁调素、低表达FPN,联合检测铁调素和FPN可以作为反映胃癌生物学行为的客观指标。
Objective To study the expression of hepcidin and membrane transferrin (FPN) in gastric carcinoma and its clinical significance. Methods Immunohistochemical staining was used to detect the expression of hepcidin and FPN in 62 cases of gastric cancer tissues and 15 cases of normal gastric mucosa tissues. The relationship between them and the clinicopathological features was analyzed. Results The expression of hepcidin in gastric cancer tissues was significantly higher than that in normal gastric mucosa tissues (56.5% vs. 20.0%, P <0.05), while the FPN positive rate was decreased (54.8% vs. 80.0%) (P <0.05). Hepcidin and FPN expression were correlated with TNM stage (P <0.05), but not with age, gender, lymph node metastasis, distant metastasis and anemia (P> 0.05). Hepcidin was negatively correlated with FPN expression (r = -0.27, P <0.05). Conclusion High expression of hepcidin and low expression of FPN in gastric cancer tissues can be used as an objective index to reflect the biological behavior of gastric cancer.