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目的：在实验性大鼠心肌梗塞模型上、观察黄芪对心梗后左室功能及胶原改建影响。方法：心梗后腹腔注射黄芪注射液２或６周，用放免法测定血浆、心肌血管紧张素Ⅱ（ＡｎｇⅡ）及血浆醛固酮（ＡＬＤ）；动脉插管测定心功能；氯胺Ｔ法测定非梗塞区（含梗塞周边区）左室心肌羟脯氨酸的水平；免疫组织化学法测量非梗塞区左室心肌Ⅰ型及Ⅲ型胶原蛋白的比值。结果：与心肌梗塞对照组比较，黄芪可降低６周时的血浆、非梗塞区心肌ＡｎｇⅡ及血浆ＡＬＤ水平（Ｐ＜００５）；２周及６周时可明显升高＋ｄｐ／ｄｔｍａｘ及－ｄｐ／ｄｔｍａｘ水平（Ｐ＜００５）；减少非梗塞区左室心肌羟脯氨酸的含量；降低非梗塞区左室心肌Ⅰ型及Ⅲ型胶原蛋白的比值（Ｐ＜００５）。结论：黄芪对心梗后左室功能及胶原改建可产生有益的影响。
OBJECTIVE: To observe the effect of radix astragali on left ventricular function and collagen remodeling after myocardial infarction in experimental rat model of myocardial infarction. METHODS: Intraperitoneal injection of Huangqi injection was administered intraperitoneally 2 or 6 weeks after myocardial infarction. Plasma, myocardial angiotensin II (AngII) and plasma aldosterone (ALD) were determined by radioimmunoassay. Arterial catheterization was used to determine cardiac function. Chloramine T method was used to measure non-infarct. The level of hydroxyproline in the left ventricular myocardium (including the infarct-peripheral area) was measured; the ratio of type I and type III collagen in the left ventricular myocardium was measured by immunohistochemistry. RESULTS: Compared with the myocardial infarction control group, Astragalus membranaceus could decrease the level of AngII and plasma ALD in plasma and non-infarction myocardium at 6 weeks (P<0.05), and significantly increase +dp/dtmax at 2 weeks and 6 weeks. The level of dp/dtmax (P<005) decreased the content of hydroxyproline in the left ventricular myocardium of the non-infarcted area and decreased the ratio of type I and type III collagen in the left ventricular myocardium (P<005). Conclusion: Astragalus has a beneficial effect on left ventricular function and collagen remodeling after MI.