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目的探讨131Ⅰ治疗非毒性甲状腺肿的临床效果。方法非毒性甲状腺肿患者106例,经131Ⅰ按甲状腺质量2.96-7.03MBq/g治疗,随访观察3-36个月,用超声检查测定甲状腺大小,观察甲状腺缩小情况。结果非毒性甲状腺肿131Ⅰ治疗12个月后痊愈43.4%(46例),显效35.8%(38例),有效11.3%(12例),无效9.4%(10例),总有效率为90.6%(96/106例)。甲状腺质量由治疗前(86.5±20.3)g缩小到治疗后(40.3±13.6)g(P<0.01)。随访3-36个月后4.7%(5例)发生甲状腺功能减退症,3.8%(4例)发生甲状腺功能亢进症。结论131Ⅰ治疗非毒性甲状腺肿安全、简便、有效。
Objective To investigate the clinical effect of 131 Ⅰ in the treatment of non-toxic goiter. Methods A total of 106 patients with non-toxic goiter were treated with 131 I according to the thyroid mass of 2.96-7.03 MBq / g. The patients were followed up for 3-36 months. The thyroid size was measured by ultrasound and the thyroid gland contraction was observed. Results After 131 I treatment, non-toxic goiter cured 43.4% (46 cases), 35.8% (38 cases), effective 11.3% (12 cases), ineffective 9.4% (10 cases), and the total effective rate was 90.6% 96/106 cases). The thyroid mass decreased from 86.5 ± 20.3 g before treatment to 40.3 ± 13.6 g after treatment (P <0.01). Hypothyroidism occurred in 4.7% (5 patients) 3-36 months after follow-up, and hyperthyroidism occurred in 3.8% (4 patients). Conclusion 131 Ⅰ treatment of non-toxic goiter safe, simple and effective.