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对8例妊娠滋养细胞肿瘤采用Seldinger穿刺技术经右股动脉插管,经髂内动脉进入子宫动脉,确定病灶及血供情况后,进一步插管接近病灶注入化疗药物,并对主供血管以明胶海绵栓塞阻断血供,并采用CAP改良方案,辅以MTX-CF方案全身化疗巩固疗程。结果8例患者除1例拒绝进一步治疗而自动出院外,疗效佳,随访1年均健在。认为通过选择性动脉插管化疗治疗妊娠滋养细胞肿瘤可使病灶组织获得较高的药物浓度,全身性副反应减少,疗效提高。
8 cases of gestational trophoblastic tumor using Seldinger puncture technique via the right femoral artery intubation through the internal iliac artery into the uterine artery to determine the lesion and blood supply, further intubation close to the injection of chemotherapy drugs, and the main blood vessels to gelatin Sponge embolization blocked blood supply, and the use of CAP improved program, combined with MTX-CF regimen chemotherapy to consolidate treatment. Results 8 patients in addition to 1 patient refused to further treatment of spontaneous discharge, good effect, follow-up in 1 year are alive. That selective arterial intubation chemotherapy for gestational trophoblastic tumor tissue can be made to obtain a higher concentration of drugs, systemic side effects decreased, the effect increased.