论文部分内容阅读
目的探讨人蛋白酶活化受体(PAR)-2在子痫前期患者胎盘组织中的表达及临床意义。方法选取2009年12月至2010年11月于吉林大学第二医院住院剖宫产分娩的子痫前期患者60例(轻度子痫前期组及重度子痫前期组各30例)和同期正常妊娠妇女30例(正常妊娠组),采用免疫组化方法检测各组胎盘组织中的PAR-2的表达,进行其灰度值分析(灰度值越大阳性越弱,灰度值越小阳性越强)。结果 PAR-2阳性表达的灰度值在轻、重度子痫前期组胎盘组织中明显低于正常妊娠组(P均<0.01);重度子痫前期组胎盘组织中PAR-2阳性表达的灰度值低于轻度子痫前期组(P<0.01)。结论胎盘组织中PAR-2表达升高与子痫前期的发病机制相关,且其表达水平可能与子痫前期的病情进展有关。
Objective To investigate the expression of human protease-activated receptor (PAR-2) in placenta of preeclampsia and its clinical significance. Methods 60 cases of preeclampsia (30 cases in mild preeclampsia group and 30 cases in severe preeclampsia group) and normal pregnancy in the same period were selected from December 2009 to November 2010 in cesarean section in the second hospital of Jilin University. The expression of PAR-2 in placenta of each group was detected by immunohistochemistry in 30 women (normal pregnancy group), and their gray values were analyzed (the greater the gray value, the weaker the positive, the lower the gray value was. Strong). Results The gray value of PAR-2 positive expression in placenta of mild and severe preeclampsia group was significantly lower than that in normal pregnancy group (all P <0.01). The gray value of PAR-2 positive expression in severe preeclampsia group Value was lower than mild preeclampsia group (P <0.01). Conclusion The increased expression of PAR-2 in placenta is associated with the pathogenesis of preeclampsia and the expression of PAR-2 may be related to the progression of preeclampsia.