【目的】探讨万古霉素联合腰大池持续引流（lumbar continuous drainage of fluid ，LCDF）治疗颅内感染的疗效。【方法】选取2014年2月至2016年2月在本院住院治疗的颅内感染患者43例，随机分为万古霉素联合腰大池持续引流治疗组（观察组，23例）和单纯万古霉素治疗组（对照组，20例），比较两组患者的治疗疗效、治疗前后脑脊液生化指标以及安全性和恢复时间的差异。【结果】观察组治疗有效率显著高于对照组；观察组治疗后白细胞计数、蛋白定量、颅内压均显著低于对照组；葡萄糖显著高于对照组；感染控制时间和症状缓解时间均低于对照组，差异均具有统计学意义（ P ＜00．5）；两组患者治疗后均未出现不良反应。【结论】万古霉素联合腰大池持续引流治疗颅内感染的疗效和恢复时间均优于单纯万古霉素治疗，值得在临床推广应用。“,”[Objective]To research the effect of vancomycin combined with LCDF (lumbar continuous drainage of fluid)in the treatment of intracranial infection .[Methods] Forty‐four cases of intracranial infection admitted in our hospital from February 2014 to February 2016 were selected and were randomly divided into vancomycin‐LCDF group (the observation group ,n =23) and vancomycin group (the control group ,n =20) .Differences of treatment effect ,biochemical indexes of cerebrospinal fluid before and after treatment , safety and recovery time of the two groups were compared .[Results] The effective rate of the observation group was significantly higher than that of the control group;The white blood cell count ,protein content and intracranial pressure in the observation group were significantly lower than those in the control group;Glucose was significantly higher than that of the control group;The time of infection control and symptom relief were lower than the control group ,the difference was statistically significant ( P <0 0.5);There were no adverse reactions in the two groups after treatment[.Conclusion] The curative effect and recovery time of vancomycin combined with LCDF in the treatment of intracranial infection were better than that of vancomycin alone ,and it is worth to be popularized in clinical application .