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目的 :探讨心肌细胞内肌动蛋白在青壮年猝死综合征死因诊断方面的价值。方法 :应用免疫组化LSAB法对 16例青壮年猝死综合征病例进行心肌细胞内肌动蛋白的研究 ,并以 15例冠心病猝死病例和 15例非心性死亡病例分别作阴性和阳性对照。结果 :16例青壮年猝死综合征病例中 ,有 13例心肌细胞内肌动蛋白明显缺失 ,2例轻度缺失 ,1例无缺失。 15例冠心病猝死阴性对照组心肌细胞内肌动蛋白均明显缺失。 15例非心性死亡阳性对照组心肌细胞内肌动蛋白均无缺失。结论 :心肌细胞内肌动蛋白免疫组化检测可作为青壮年猝死综合征死因诊断的指标。
Objective: To investigate the value of actin in cardiomyocytes in the diagnosis of sudden death syndrome in young adults. Methods: 16 cases of sudden death syndrome in young adults were studied by immunohistochemical LSAB method, and 15 cases of sudden death of coronary heart disease and 15 cases of non-cardiac death were used as negative and positive control respectively. Results: Of the 16 cases of sudden death syndrome in young adults, 13 cases of myocardial cells were significantly deficient in actin, 2 cases were mildly deleted and 1 case was missing. 15 cases of coronary heart disease sudden negative control group myocardial cells were significantly missing actin. 15 cases of non-cardiac death positive control group myocardial cells within the absence of actin. Conclusion: The detection of actin immunohistochemistry in cardiomyocytes can be used as an indicator of the cause of sudden death in young adults.