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目的观察口服普萘洛尔治疗婴幼儿眼部血管瘤的有效性及安全性。方法 24位年龄1~10个月的眼部血管瘤患儿,排除使用普萘洛尔禁忌症后,按普萘洛尔2mg/kg/日剂量进行口服治疗,监测心率血压至少72小时后保持出院继续治疗并保持随访。每月复查肿块B超、血糖、心率及血压,观察评估血管瘤变化及处理不良反应,根据肿块大小及B超情况择期减量至1mg/kg/日维持量,治疗疗程为6~18个月,并对治疗效果进行评价。结果24位病人通过治疗后,23人外观肿块消失者,1人仍可见眼睑肿胀、可扪及肿块。效果评价为Ⅳ级者23人(23/24,95.83%),Ⅱ级者1人(1/24,4.17%)。所有病人服药期间未见明显心率及血压降低。随访中3位年龄小于3个月的患儿出现睡眠不安、肝功能异常及低血糖反应。结论对于婴幼儿眼部血管瘤,口服普萘洛尔是一种安全有效的治疗方法。
Objective To observe the effectiveness and safety of oral propranolol in the treatment of infantile hemangiomas. Methods Twenty-four patients with ocular hemangiomas aged 1 to 10 months were treated orally with propranolol 2 mg / kg / day after excluding contraindications to propranolol. Heart rate and blood pressure were monitored at least 72 hours later Discharged to continue treatment and follow-up. Monthly review of tumor mass B, blood glucose, heart rate and blood pressure, observed and evaluated changes in hemangiomas and treatment of adverse reactions, according to the size of the tumor and B-elective reduction to 1mg / kg / day maintenance dose of 6 to 18 months , And evaluate the treatment effect. Results 24 patients after treatment, the appearance of 23 people disappeared, one still visible eyelid swelling, palpable mass. The results were rated as grade Ⅳ 23 (23/24, 95.83%), grade Ⅱ 1 (1/24, 4.17%). No significant heart rate and blood pressure were seen during the medication in all patients. Three children younger than 3 months at follow-up had restlessness, abnormal liver function and hypoglycemia. Conclusion For prophylactic eye hemangiomas, oral propranolol is a safe and effective treatment.